Journal
CELLS
Volume 10, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/cells10010187
Keywords
RNA therapeutics; cell therapy; cardiovascular regeneration; inflammatory signaling; nuclear reprogramming; iPSCs; transdifferentiation; cardiovascular ageing
Categories
Funding
- George And Angelina Kostas Research Center for Cardiovascular Nanomedicine
- National Institutes of Health NIH [R01s HL133254, HL148338]
- Cancer Prevention Research Institute of Texas CPRIT [RP200619, RP150611]
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mRNA has emerged as a key biomolecule for therapy development during the COVID-19 pandemic, with potential applications ranging from cancer immunotherapy to vaccine development. Recent advancements in RNA therapeutics have overcome challenges associated with this drug molecule, enabling its use in stem cell generation and cardiovascular regeneration.
mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target undruggable diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.
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