Urogenital Schistosomiasis-History, Pathogenesis, and Bladder Cancer

Schistosomiasis is the most important helminthiasis worldwide in terms of morbidity and mortality. Most of the infections occurs in Africa, which about two thirds are caused by Schistosoma haematobium. The infection with S. haematobium is considered carcinogenic leading to squamous cell carcinoma (SCC) and urothelial carcinoma of the urinary bladder. Additionally, it is responsible for female genital schistosomiasis leading to infertility and higher risk of human immunodeficiency virus (HIV) transmission. Remarkably, a recent outbreak in Corsica (France) drew attention to its potential re-mergence in Southern Europe. Thus far, little is known related to host-parasite interactions that trigger carcinogenesis. However, recent studies have opened new avenues to understand mechanisms on how the parasite infection can lead cancer and other associated pathologies. Here, we present a historical perspective of schistosomiasis, and review the infection-associated pathologies and studies on host-parasite interactions that unveil tentative mechanisms underlying schistosomiasis-associated carcinogenesis.

Automated summary

Schistosomiasis is the most important helminthiasis in the world, with the majority of infections occurring in Africa, but recent outbreaks in Corsica, France have raised concerns about its potential re-emergence in Southern Europe. Infection with Schistosoma can lead to various cancers and pathologies, and there is still limited understanding on the mechanisms of host-parasite interactions that trigger carcinogenesis.