Journal
ACTA PHARMACEUTICA SINICA B
Volume 11, Issue 9, Pages 2783-2797Publisher
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2021.01.001
Keywords
Exosomes; Tumor immunity; Tumor metastasis; Drug resistance; Biomarkers; Drug delivery
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Funding
- CAMS Innovation Fund for Medical Sciences (China) [2016-I2M-3-007]
- Technology Major Projects for 'Major New Drugs Innovation and Development' (China) [2018ZX09711001-005-025, 2018ZX09711001-012]
- National Natural Science Foundation of China [81703536, 81803584]
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Exosomes are cell-derived nanovesicles that play essential roles in intercellular communication, cancer progression, and drug delivery. They have potential applications in cancer diagnosis, treatment, and research.
Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon fusion of multivesicular bodies with the cell surface. They can transport nucleic acids, proteins, and lipids for intercellular communication and activate signaling pathways in target cells. In cancers, exosomes may participate in growth and metastasis of tumors by regulating the immune response, blocking the epithelial-mesenchymal transition, and promoting angiogenesis. They are also involved in the development of resistance to chemotherapeutic drugs. Exosomes in liquid biopsies can be used as non-invasive bio-markers for early detection and diagnosis of cancers. Because of their amphipathic structure, exosomes are natural drug delivery vehicles for cancer therapy. (c) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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