Strontium ions protect hearts against myocardial ischemia/reperfusion injury

Timely restoration of blood supply following myocardial infarction is critical to save the infarcted myocardium, while reperfusion would cause additional damage. Strontium ions have been shown to promote angiogenesis, but it is unknown whether they can save the damaged myocardium. We report that myocardial ischemia/reperfusion (I/R)-induced functional deterioration and scar formation were notably attenuated by injection of strontium ion-containing composite hydrogels into murine infarcted myocardium at 20 minutes of reperfusion following 60 minutes of ischemia. These beneficial effects were accompanied by reduced cardiomyocyte apoptosis and increased angiogenesis. The effects of strontium ions were further confirmed by the enhanced viability of cardiomyocytes and stimulated angiogenesis in vitro. These findings are the first to reveal the cardioprotective effects of strontium ions against I/R injury, which may provide a new therapeutic approach to ischemic heart disease at a lower cost, with higher stability, and with potentially greater safety.

Automated summary

The injection of composite hydrogels containing strontium ions into infarcted myocardium after ischemia and reperfusion in mice significantly attenuated functional deterioration and scar formation, while also reducing cardiomyocyte apoptosis and promoting angiogenesis. These findings suggest the cardioprotective effects of strontium ions against ischemia/reperfusion injury, providing a potential new therapeutic approach for ischemic heart disease.