Journal
CHEMISTRYSELECT
Volume 6, Issue 4, Pages 717-725Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202003948
Keywords
Anticancer agents; isatin; 1; 4-dihydropyridine; triazole; molecular docking
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A series of novel triazole linked isatin-dihydropyridine hybrids have been synthesized and tested for their anti proliferative activity against human cancer cell lines. Compound N2 showed the highest inhibitory action and may be an excellent drug-like candidate for further pursuit.
A series of novel triazole linked isatin-dihydropyridine hybrids (N1-N15) have been synthesized and examined for their anti proliferative activity against human cancer cell lines viz. HeLa, Huh-7, PC-3, IMR-32 and MCF-7. All of the synthesized hybrids have shown moderate to potent cytotoxicity against all the tested cell lines except IMR-32. Compounds N1, N2 and N13 have displayed an enhanced inhibitory potency against Huh-7 cell line as compared to the standard drug, doxorubicin. Out of the three, N2 has shown the highest in vitro inhibitory action with IC50 values of 6.73 +/- 0.33 mu M and 17.94 +/- 0.23 mu M against Huh-7 and MCF-7 cell lines, respectively. The docking studies of these most potent compounds have also been investigated which identified that N2 might be an excellent drug-like candidate worthy of further pursuit.
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