Journal
CHEMISTRYSELECT
Volume 6, Issue 1, Pages 68-81Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202004245
Keywords
Humic acid; Solvent-free; Bis(indolyl)methane; Bis(pyrazolyl)methane; Bis-coumarin; Bis-lawsone
Categories
Funding
- CSIR, New Delhi
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The study demonstrates that humic acid can be utilized as an efficient and environmentally friendly catalyst for the preparation of various organic compounds, with advantages such as non-toxicity, biodegradability, low catalyst loading, and good functional group tolerance. This strategy has significant environmental implications, and humic acid can be reused multiple times without losing its activity.
Humic acid, a biodegradable, non-toxic and easily accessible high molecular weight organocatalyst has been explored for the straightforward and environmentally benign approach towards the preparation of diverse array of functionalized bis(indolyl)methanes, bis(pyrazolyl)methanes, bis-coumarins and bis-lawsones by the reaction of a vast range of aldehydes with indole, 3-methyl-1-phenyl pyrazolone, 4-hydroxycoumarin and 2-hydroxynaphthalene-1,4-dione respectively under solvent-free condition. These protocols proceed without any hazardous solvents, toxic metal catalysts and harsh reaction conditions. In addition, low catalyst loading, good yield and excellent functional group tolerance are the key advantages of these protocols. The used catalyst and solvent-free approach make this strategy safe to our mother earth. For the first time reusability of humic acid was investigated and found that it can be recycled up to fifth run without any significant loss of its activity at the end of the reaction. Some bioactive molecules such as arundine, trisindoline and vibribdole A were easily synthesized in our lab by utilizing this designed strategy.
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