Journal
APPLIED BIOLOGICAL CHEMISTRY
Volume 63, Issue 1, Pages -Publisher
SPRINGER SINGAPORE PTE LTD
DOI: 10.1186/s13765-020-00563-5
Keywords
β -Glucogallin; Filaggrin; Fusidium coccineum; HAS3; Keratinocyte
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Soil has been used for treatment of wound and skin diseases and for cosmetic purposes. Fusidium coccineum (FC) SA-1FC (Ascomycota) is a fungus found in nature, and its by-products are present in humid soils with plant humus. This study investigates the medium of fermented FC as a covering for all skin problems, including dryness, inflammation, and wounds. A preliminary study revealed that an alcohol extract of FC had a skin-enhancing effect, and thin-layer chromatography revealed a major component in a non-polar fraction. Here we identify a major compound isolated from a non-polar fraction as beta-glucogallin. The mRNA levels of filaggrin and HAS3 are upregulated by FC and beta-glucogallin treatment in keratinocytes and immortalized human keratinocytes cells. In addition, FC and beta-glucogallin exert anti-inflammatory effects by suppressing expression of interleukin-4/poly(I:C)-induced chemokines and inflammatory cytokines. In fibroblasts, Hs68 cells, FC and beta-glucogallin stimulate cell migration. These results suggest that FC and beta-glucogallin can enhance skin barrier function.
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