Journal
ACS SENSORS
Volume 5, Issue 12, Pages 3988-3998Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.0c01757
Keywords
photonic crystal; interpenetrating polymer network; flexible; biosensor; urea; cholesteric liquid crystal
Funding
- National Research Foundation of Korea [2020R1A2B5B02001556]
- National Research Foundation of Korea [4299990414523] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A wearable noninvasive biosensor for in situ urea detection and quantification was developed using a urease-immobilized photonic interpenetrating polymer network (IPNurease) film. The photonic IPN film was intertwined with solid-state cholesteric liquid crystals (CLCsolid) and a poly(acrylic acid) (PAA) network on a flexible poly(ethylene terephthalate) substrate adhered to a poly(dimethylsiloxane) (PDMS) chip that was fabricated using an aluminum mold. The presence of urea in the chemical matrix of human sweat red-shifted the reflected color of the photonic IPNurease film, and quantification was achieved by observing the wavelength at the photonic band gap (lambda(PBG)) with a limit of detection of 0.4 mM and a linear range of 0.9-50 mM. The color changes observed in the photonic IPN film were digitalized using the CIE 1931 xy coordinates on a cell phone image, thereby enabling fast, direct diagnosis via a downloadable app. This novel PDMS chip can be expanded for use with other biosensors.
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