Functional Constipation and the Gut Microbiome in Children: Preclinical and Clinical Evidence

Functional constipation is a common condition in childhood with significant impact on patients' quality of life and on health care resources. Functional constipation is characterized by decreased bowel movements and/or hard stools, which cause significant distress for children and their caregivers. While the term functional may imply the absence of organic causes with a focus on behavioral aspects, 40% of children continue to have symptoms beyond conventional management with one in four children continuing to experience constipation into adulthood. The refractory and chronic nature of constipation highlights the importance of considering a range of pathophysiological mechanisms, including the potential role of the gut microbiome. In this review, we provide an overview of preclinical and clinical studies that focus on the potential mechanisms through which the gut microbiome might contribute to the clinical presentation of functional constipation in pediatrics.

Automated summary

Functional constipation is a common condition in childhood that continues to persist in a significant number of children despite conventional management. The refractory and chronic nature of constipation emphasizes the importance of considering various pathophysiological mechanisms, including the potential role of the gut microbiome.