Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2020.572089
Keywords
signaling; kinase; Adipose; Brown; P38; p38 mitogen-activated protein kinase(s)
Categories
Funding
- Spanish grant MINECO-FEDER [SAF2015-74112-JIN]
- Fundacion AECC [INVES20026LEIV]
- Spanish State programme for the Promotion of Talent and its Employment [PRE2018-083631]
- EFSD/Lilly grants
- CNIC IPP FP7 Marie Curie Programme [PCOFUND-2012600396]
- EFSD Rising Star award
- JDC-2018-Incorporacion [MIN/JDC1802]
- European Union Seventh Framework Programme (FP7/2007-2013) [ERC 260464]
- EFSD/Lilly European Diabetes Research Programme
- BBVA Foundation Leonardo Grants program for Researchers and Cultural Creators [IN[17]_ BBM_ BAS_0066]
- MINECO-FEDER [SAF2016-79126-R]
- Comunidad de Madrid [IMMUNOTHERCAN-CM S2010/BMD-2326, B2017/BMD-3733]
- Instituto de Salud Carlos III (ISCIII)
- Ministerio de Ciencia, Innovacion y Universidades (MCNU)
- Pro CNIC Foundation
- Severo Ochoa Center of Excellence [SEV-2015-0505]
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The complex functions of adipose tissue have been a focus of research interest over the past twenty years. Adipose tissue is not only the main energy storage depot, but also one of the largest endocrine organs in the body and carries out crucial metabolic functions. Moreover, brown and beige adipose depots are major sites of energy expenditure through the activation of adaptive, non-shivering thermogenesis. In recent years, numerous signaling molecules and pathways have emerged as critical regulators of adipose tissue, in both homeostasis and obesity-related disease. Among the best characterized are members of the p38 kinase family. The activity of these kinases has emerged as a key contributor to the biology of the white and brown adipose tissues, and their modulation could provide new therapeutic approaches against obesity. Here, we give an overview of the roles of the distinct p38 family members in adipose tissue, focusing on their actions in adipogenesis, thermogenic activity, and secretory function.
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