Journal
CANCER MANAGEMENT AND RESEARCH
Volume 12, Issue -, Pages 13259-13271Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S279672
Keywords
glycolysis; autophagy; lung cancer; lactate; metabolism
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Funding
- Zhenjiang Key R&D Program - Social Development [SH2020026]
- Natural Science Foundation of Jiangsu Province [BK20191429]
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Autophagy is a critical cellular process that generally protects cells and organisms from harsh environment, including limitations in adenosine triphosphate (ATP) availability or a lack of essential nutrients. Metabolic reprogramming, a hallmark of cancer, has recently gained interest in the area of cancer therapy. It is well known that cancer cells prefer to utilize glycolysis rather than oxidative phosphorylation (OXPHOS) as their major energy source to rapidly generate ATP even in aerobic environment called the Warburg effect. Both autophagy and glycolysis play essential roles in pathological processes of cancer. A mechanism of metabolic changes to drive tumor progression is its ability to regulate autophagy. This review will elucidate the role and the mechanism of glycolysis in regulating autophagy during tumor growth. Indeed, understanding how glycolysis can modulate cellular autophagy will enable more effective combinatorial therapeutic strategies.
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