Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 8, Issue 1, Pages 288-293Publisher
WILEY
DOI: 10.1002/acn3.51261
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Funding
- Epilepsy Foundation's Epilepsy Innovation Institute My Seizure Gauge Project
- NIHR Biomedical Research Centre
- MRC Centre for Neurodevelopmental Disorders [MR/N026063/1]
- EPSRC Centre for Predictive Modelling in Healthcare [EP/N014391/1]
- RADAR-CNS project [115902]
- EPSRC [EP/N014391/1] Funding Source: UKRI
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This study describes the longest period of subcutaneous EEG monitoring in a 35-year-old female with refractory epilepsy, showing substantial agreement between reported and recorded seizures, although some clustered seizures were missed. Significant seizure cycles were identified at circadian and multidien timescales using circular statistics. This neurophysiological tool enables electrographic seizure monitoring and analysis of long-term seizure cycles.
We describe the longest period of subcutaneous EEG (sqEEG) monitoring to date, in a 35-year-old female with refractory epilepsy. Over 230 days, 4791/5520 h of sqEEG were recorded (86%, mean 20.8 [IQR 3.9] hours/day). Using an electronic diary, the patient reported 22 seizures, while automatically-assisted visual sqEEG review detected 32 seizures. There was substantial agreement between days of reported and recorded seizures (Cohen's kappa 0.664), although multiple clustered seizures remained undocumented. Circular statistics identified significant sqEEG seizure cycles at circadian (24-hour) and multidien (5-day) timescales. Electrographic seizure monitoring and analysis of long-term seizure cycles are possible with this neurophysiological tool.
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