Journal
CELL SYSTEMS
Volume 12, Issue 1, Pages 102-+Publisher
CELL PRESS
DOI: 10.1016/j.cels.2020.11.010
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Funding
- Schmidt Futures
- Google Cloud Platform grant
- NIH [R01CA218094]
- C3.AI DTI Award
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The research found that some individuals may not robustly display SARS-CoV-2 subunit peptides by MHC molecules, and introduced an augmentation strategy to improve the population coverage of pathogen peptide display by adding a small number of SARS-CoV-2 peptides.
Subunit vaccines induce immunity to a pathogen by presenting a component of the pathogen and thus inherently limit the representation of pathogen peptides for cellular immunity-based memory. We find that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subunit peptides may not be robustly displayed by the major histocompatibility complex (MHC) molecules in certain individuals. We introduce an augmentation strategy for subunit vaccines that adds a small number of SARS-CoV-2 peptides to a vaccine to improve the population coverage of pathogen peptide display. Our population coverage estimates integrate clinical data on peptide immunogenicity in convalescent COVID-19 patients and machine learning predictions. We evaluate the population coverage of 9 different subunits of SARS-CoV-2, including 5 functional domains and 4 full proteins, and augment each of them to fill a predicted coverage gap.
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