Journal
ONCOIMMUNOLOGY
Volume 10, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2020.1863626
Keywords
Photosensitizer; photodynamic therapy; immunogenic cell death; antitumor immunity
Categories
Funding
- National Cancer Institute (NCI) of the National Institutes of Health (NIH) [R01CA222227]
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A new class of ruthenium-based photosensitizers have been discovered to induce potent cytotoxicity and immunogenic cell death in melanoma cells when activated by NIR light, potentially establishing protective antitumor immunity.
We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.
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