Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.

Automated summary

A new class of ruthenium-based photosensitizers have been discovered to induce potent cytotoxicity and immunogenic cell death in melanoma cells when activated by NIR light, potentially establishing protective antitumor immunity.