Journal
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
Volume 101, Issue 1, Pages 47-50Publisher
SPRINGER
DOI: 10.1007/s41745-020-00216-y
Keywords
Immunological synapse; Fluorescence imaging; Microscopy; Actin cytoskeleton; Actin foci
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Funding
- Koch Institute Support (core) Grant from National Cancer Institute [P30-CA14051]
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T lymphocytes detect pathogens through the interaction of their T cell receptor with pathogen-derived peptides presented on infected cells. The formation of immunological synapse between T cells and infected cells is crucial for T cell activation, involving dynamic actin polymerization.
T lymphocytes (T cells) are the major mediators of adaptive immune response. They detect pathogens primarily via the interaction of their T cell receptor (TCR) with the cognate pathogen-derived peptide displayed in the context of MHC on the infected cell. A critical step in T cell activation is the formation of immunological synapse, a specialized cell-cell conjugate interface between the T cell and infected cell, where massive TCR-induced actin remodeling and polymerization take place. Dynamic actin polymerization at the immunological synapse is essential for T cell activation and subsequently, immune response.
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