Journal
FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.624144
Keywords
T cell receptor; PD-1; brain-resident memory CD8 T cells; virus; neuroinflammation
Categories
Funding
- National Institute of Neurological Disorders and Stroke
- National Cancer Institute [R01NS088367, R01NS092662, F32NS106730, T32CA060395]
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Tissue-resident memory (T-RM) CD8 T cells are a type of immune cells that provide early defense against regional pathogens and are predominantly located in nonlymphoid tissues. These cells show distinct transcriptional and phenotypic differences from central-memory T cells and effector-memory T cells, and these differences vary across barrier tissues and non-barrier organs. The factors contributing to the development and maintenance of brain T-RM involve T cell receptor (TCR) signal strength, duration, and modulation by inhibitory markers to balance activation and neuronal preservation.
Tissue-resident memory (T-RM) CD8 T cells provide early frontline defense against regional pathogen reencounter. CD8 T-RM are predominantly parked in nonlymphoid tissues and do not circulate. In addition to this anatomic difference, T-RM are transcriptionally and phenotypically distinct from central-memory T cells (T-CM) and effector-memory T cells (T-EM). Moreover, T-RM differ phenotypically, functionally, and transcriptionally across barrier tissues (e.g., gastrointestinal tract, respiratory tract, urogenital tract, and skin) and in non-barrier organs (e.g., brain, liver, kidney). In the brain, T-RM are governed by a contextual milieu that balances T-RM activation and preservation of essential post-mitotic neurons. Factors contributing to the development and maintenance of brain T-RM, of which T cell receptor (TCR) signal strength and duration is a central determinant, vary depending on the infectious agent and modulation of TCR signaling by inhibitory markers that quell potentially pathogenic inflammation. This review will explore our current understanding of the context-dependent factors that drive the acquisition of brain (b)T-RM phenotype and function, and discuss the contribution of T-RM to promoting protective immune responses in situ while maintaining tissue homeostasis.
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