Related references
Note: Only part of the references are listed.Long-term surviving cancer patients as a source of therapeutic TCR
Else Marit Inderberg et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)
Lck bound to coreceptor is less active than free Lck
Qianru Wei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR
Sara Ghorashian et al.
NATURE MEDICINE (2019)
NK cells specifically TCR-dressed to kill cancer cells
Nadia Mensali et al.
EBIOMEDICINE (2019)
Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerations
Robert Weinkove et al.
CLINICAL & TRANSLATIONAL IMMUNOLOGY (2019)
Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains
Daniel T. Harris et al.
JOURNAL OF IMMUNOLOGY (2018)
Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density
John R. James
SCIENCE SIGNALING (2018)
Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex
Caleb R. Glassman et al.
CELL REPORTS (2018)
Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density
John R. James
SCIENCE SIGNALING (2018)
In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin's Lymphomas
Carlos A. Ramos et al.
MOLECULAR THERAPY (2018)
Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function
Alexander I. Salter et al.
SCIENCE SIGNALING (2018)
CD4+ T cell help in cancer immunology and immunotherapy
Jannie Borst et al.
NATURE REVIEWS IMMUNOLOGY (2018)
Human leucocyte antigen class I-redirected anti-tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells
M. P. Tan et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)
Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3
Yong-Chen Lu et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms
Danilo Presotto et al.
FRONTIERS IN IMMUNOLOGY (2017)
Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System
Drew C. Deniger et al.
MOLECULAR THERAPY (2016)
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
Alena Gros et al.
NATURE MEDICINE (2016)
Functional evidence for TCR-intrinsic specificity for MHCII
Heather L. Parrish et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry
Daniel T. Harris et al.
STRUCTURE (2016)
Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors
Daniel T. Harris et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells
Diana Knies et al.
ONCOTARGET (2016)
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
Adrienne H. Long et al.
NATURE MEDICINE (2015)
A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization
Heather L. Parrish et al.
PLOS ONE (2015)
Direct tumor recognition by a human CD4+ T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses
Junko Matsuzaki et al.
SCIENTIFIC REPORTS (2015)
A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control
Jennifer D. Stone et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2014)
Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance
Ondrej Stepanek et al.
CELL (2014)
Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC
Stephen P. Persaud et al.
NATURE IMMUNOLOGY (2014)
Lck Availability during Thymic Selection Determines the Recognition Specificity of the T Cell Repertoire
Francois Van Laethem et al.
CELL (2013)
A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells
Jun Huang et al.
IMMUNITY (2013)
T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens
Judith N. Mandl et al.
IMMUNITY (2013)
SHP-1 phosphatase activity counteracts increased T cell receptor affinity
Michael Hebeisen et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy
Shi Zhong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies
Milos Aleksic et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains
D. H. Aggen et al.
GENE THERAPY (2012)
Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+ T Cell Responsiveness
Melita Irving et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Incorporation of Transmembrane Hydrophobic Mutations in the TCR Enhance Its Surface Expression and T Cell Functional Avidity
Astar Haga-Friedman et al.
JOURNAL OF IMMUNOLOGY (2012)
Distinct CD4+ helper T cells involved in primary and secondary responses to infection
K. Scott Weber et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4
Yiyuan Yin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection
Francois Van Laethem et al.
TRENDS IN IMMUNOLOGY (2012)
Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen
Sharyn Thomas et al.
BLOOD (2011)
hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes
Else M. Inderberg Suso et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2011)
Telomerase Peptide Vaccination Combined with Temozolomide: A Clinical Trial in Stage IV Melanoma Patients
Jon Amund Kyte et al.
CLINICAL CANCER RESEARCH (2011)
Telomerase Peptide Vaccination in NSCLC: A Phase II Trial in Stage III Patients Vaccinated after Chemoradiotherapy and an 8-Year Update on a Phase I/II Trial
Paal Fr. Brunsvig et al.
CLINICAL CANCER RESEARCH (2011)
Late Arrival: Recruiting Coreceptors to the T Cell Receptor Complex
P. Anton van der Merwe et al.
IMMUNITY (2011)
Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination
Ning Jiang et al.
IMMUNITY (2011)
Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses
Emily Corse et al.
JOURNAL OF IMMUNOLOGY (2011)
CD28 Costimulation Impairs the Efficacy of a Redirected T-cell Antitumor Attack in the Presence of Regulatory T cells Which Can Be Overcome by Preventing Lck Activation
David M. Kofler et al.
MOLECULAR THERAPY (2011)
High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice
Jin Hee Kim et al.
PLOS ONE (2011)
Initiation of TCR phosphorylation and signal transduction
Nicholas R. J. Gascoigne et al.
FRONTIERS IN IMMUNOLOGY (2011)
Coexpression of the T-cell receptor constant α domain triggers tumor reactivity of single-chain TCR-transduced human T cells
Ralf-Holger Voss et al.
BLOOD (2010)
Hard and soft lesions underlying the HLA Class I alterations in cancer cells: implications for immunotherapy
Federico Garrido et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Naive tumor-specific CD4+ T cells differentiated in vivo eradicate established melanoma
Ying Xie et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
Sergio A. Quezada et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function
Daphne A. Schmid et al.
JOURNAL OF IMMUNOLOGY (2010)
High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics
Stephen P. Persaud et al.
MOLECULAR IMMUNOLOGY (2010)
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
Gavin M. Bendle et al.
NATURE MEDICINE (2010)
An improved yeast transformation method for the generation of very large human antibody libraries
Lorenzo Benatuil et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2010)
ITAM-mediated Signaling by the T-Cell Antigen Receptor
Paul E. Love et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Attenuated T Cell Responses to a High-Potency Ligand In Vivo
Emily Corse et al.
PLOS BIOLOGY (2010)
The duration of TCR/pMHC interactions regulates CTL effector function and tumor-killing capacity
Erick Riquelme et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2009)
Cutting Edge: Inhibitory Effects of CD4 and CD8 on T Cell Activation Induced by High-Affinity Noncognate Ligands
Adam S. Chervin et al.
JOURNAL OF IMMUNOLOGY (2009)
Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain VαVβ fragments
Sarah A. Richman et al.
MOLECULAR IMMUNOLOGY (2009)
Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity
Natalie A. Bowerman et al.
MOLECULAR IMMUNOLOGY (2009)
Complete but curtailed T-cell response to very low-affinity antigen
Dietmar Zehn et al.
NATURE (2009)
Human TCR that incorporate CD3ζ induce highly preferred pairing between TCRα and β chains following gene transfer
Zsolt Sebestyen et al.
JOURNAL OF IMMUNOLOGY (2008)
Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions
Paul F. Robbins et al.
JOURNAL OF IMMUNOLOGY (2008)
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor
Angel Varela-Rohena et al.
NATURE MEDICINE (2008)
Molecular design of the C alpha beta interface favors specific pairing of introduced TCR alpha beta in human T cells
Ralf-Holger Voss et al.
JOURNAL OF IMMUNOLOGY (2008)
CD8+ T cell activation is governed by TCR-Peptide/MHC affinity, not dissociation rate
Shaomin Tian et al.
JOURNAL OF IMMUNOLOGY (2007)
Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties
Bruno Laugel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Yeast surface display for protein engineering and characterization
S. Annie Gai et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2007)
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
Mark A. Daniels et al.
NATURE (2006)
Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer
Paal F. Brunsvig et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2006)
The study of high-affinity TCRs reveals duality in T cell recognition of antigen: Specificity and degeneracy
David L. Donermeyer et al.
JOURNAL OF IMMUNOLOGY (2006)
CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse
Regina Tavano et al.
NATURE CELL BIOLOGY (2006)
Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines
Rachel H. McMahan et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Generation of T-cell receptor retrogenic mice
Jeff Holst et al.
NATURE PROTOCOLS (2006)
Isolating and engineering human antibodies using yeast surface display
Ginger Chao et al.
NATURE PROTOCOLS (2006)
Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function
KS Weber et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3
LK Chlewicki et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Lipid rafts: resolution of the 'fyn problem?
D Filipp et al.
MOLECULAR IMMUNOLOGY (2004)
Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody
KS Midelfort et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation
PD Holler et al.
IMMUNITY (2003)
Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling
R Fragoso et al.
JOURNAL OF IMMUNOLOGY (2003)
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
M Krogsgaard et al.
MOLECULAR CELL (2003)
Direct observation of ligand recognition by T cells
DJ Irvine et al.
NATURE (2002)
Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene
Q Wang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule
JH Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Efficient cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex
AM Kalergis et al.
NATURE IMMUNOLOGY (2001)
In vitro evolution of a T cell receptor with high affinity for peptide/MHC
PD Holler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Share Paper
