4.8 Review

Recent Advances in Camel Immunology

Journal

FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.614150

Keywords

camel (Camelus dromedarius); immune; overview; review— systematic; leukocytes; monocyte subpopulations

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Camels are highly adapted to extreme desert ecosystems and have a strong resistance to pathogens, leading to increased interest in camel immunology. Research focuses on the phenotype and functionality of camel leukocyte subpopulations under different physiological and pathological conditions. Despite progress, gaps remain in understanding camel immune system components such as innate recognition mechanisms and characterization of specific immune cells.
Camels are domesticated animals that are highly adapted to the extreme desert ecosystem with relatively higher resistance to a wide range of pathogens compared to many other species from the same geographical region. Recently, there has been increased interest in the field of camel immunology. As the progress in the analysis of camel immunoglobulins has previously been covered in many recent reviews, this review intends to summarize published findings related to camel cellular immunology with a focus on the phenotype and functionality of camel leukocyte subpopulations. The review also describes the impact of different physiological (age and pregnancy) and pathological (e.g. infection) conditions on camel immune cells. Despite the progress achieved in the field of camel immunology, there are gaps in our complete understanding of the camel immune system. Questions remain regarding innate recognition mechanisms, the functional characterization of antigen-presenting cells, and the characterization of camel NK and cytotoxic T cells.

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