Journal
ADVANCED SCIENCE
Volume 8, Issue 4, Pages -Publisher
WILEY
DOI: 10.1002/advs.202003762
Keywords
argon plasma treatment; polymer characterization; polymeric biomaterials; secondary electron emission; secondary electron hyperspectral imaging
Categories
Funding
- EPSRC [EP/N008065/1, EP/R513313/1]
- Royal Thai Government
- Leibniz Association [SAW-2017-IPHT-1]
- EPSRC [EP/N008065/1, 2126547] Funding Source: UKRI
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Understanding the effects of sterilization methods on biomaterial surface is crucial for clinical deployment. This study compared surfaces from autoclave sterilization with low-pressure Argon glow discharge to explore a potential new sterilization method, finding that the latter showed promising results for further optimization as a potential terminal sterilization method.
Understanding the effects that sterilization methods have on the surface of a biomaterial is a prerequisite for clinical deployment. Sterilization causes alterations in a material's surface chemistry and surface structures that can result in significant changes to its cellular response. Here we compare surfaces resulting from the application of the industry standard autoclave sterilisation to that of surfaces resulting from the use of low-pressure Argon glow discharge within a novel gas permeable packaging method in order to explore a potential new biomaterial sterilisation method. Material surfaces are assessed by applying secondary electron hyperspectral imaging (SEHI). SEHI is a novel low-voltage scanning electron microscopy based characterization technique that, in addition to capturing topographical images, also provides nanoscale resolution chemical maps by utilizing the energy distribution of emitted secondary electrons. Here, SEHI maps are exploited to assess the lateral distributions of diverse functional groups that are effected by the sterilization treatments. This information combined with a range of conventional surface analysis techniques and a cellular metabolic activity assay reveals persuasive reasons as to why low-pressure argon glow discharge should be considered for further optimization as a potential terminal sterilization method for PGS-M, a functionalized form of poly(glycerol sebacate) (PGS).
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