Journal
ADVANCED SCIENCE
Volume 8, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/advs.202002825
Keywords
biomedical devices; cell– cell communication; high‐ throughput sequencing; intercellular communication
Categories
Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [P30 AR069620]
- 3M Foundation
- American Federation for Aging Research Grant for Junior Faculty
- Department of Defense and Congressionally Directed Medical Research Program [W81XWH2010336]
- University of Michigan Geriatrics Center [P30 AG024824]
- National Institute of Aging [P30 AG024824]
- National Institute for Biomedical Imaging and Bioengineering Training Award [T32 EB005582]
- National Institutes of Health [1R21CA245597-01]
- Breast Cancer Research Foundation
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR002240]
- U.S. Department of Defense (DOD) [W81XWH2010336] Funding Source: U.S. Department of Defense (DOD)
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Multicellular organisms rely on intercellular communication networks to maintain homeostasis, and studying this communication is crucial for disease prevention, aging, and therapeutic development. Recent advances in microengineering and high-throughput genomics provide new ways to study cellular interactions.
All multicellular organisms rely on intercellular communication networks to coordinate physiological functions. As members of a dynamic social network, each cell receives, processes, and redistributes biological information to define and maintain tissue homeostasis. Uncovering the molecular programs underlying these processes is critical for prevention of disease and aging and development of therapeutics. The study of intercellular communication requires techniques that reduce the scale and complexity of in vivo biological networks while resolving the molecular heterogeneity in omic layers that contribute to cell state and function. Recent advances in microengineering and high-throughput genomics offer unprecedented spatiotemporal control over cellular interactions and the ability to study intercellular communication in a high-throughput and mechanistic manner. Herein, this review discusses how salient engineered approaches and sequencing techniques can be applied to understand collective cell behavior and tissue functions.
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