4.7 Article

Effects of Carbon Nanowalls (CNWs) Substrates on Soft Ionization of Low-Molecular-Weight Organic Compounds in Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS)

Journal

NANOMATERIALS
Volume 11, Issue 2, Pages -

Publisher

MDPI
DOI: 10.3390/nano11020262

Keywords

carbon nanowalls; surface-assisted laser desorption; ionization mass spectrometry; plasma-enhanced chemical vapor deposition

Funding

  1. Japan Society for the Promotion of Science (JSPS)
  2. Ministry of Science, Education and Sport of the Republic of Slovenia (MESS) under the Japan-Slovenia Research Cooperative Program [JPJSBP120205002]
  3. JSPS [JP19H05462]

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Carbon nanowalls (CNWs) were used in SALDI-MS measurements to detect low-molecular-weight organic compounds. CNWs with narrower wall-to-wall distances showed higher survival yield values and increased signal-to-noise ratios for amino acid signals.
Carbon nanowalls (CNWs), which are vertically oriented multi-layer graphene sheets, were employed in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) measurements to detect low-molecular-weight organic compounds. CNWs substrates with widely different wall-to-wall distances from 142 to 467 nm were synthesized using a radical-injection plasma-enhanced chemical vapor deposition (RI-PECVD) system with nanosecond pulse biasing to a sample stage. When survival yield (SY) values of N-benzylpyridinium chloride (N-BP-Cl) were examined, which is commonly used to evaluate desorption/ionization efficiency, a narrower wall-to-wall distance presented a higher SY value. The highest SY value of 0.97 was realized at 4 mJ/cm(2) for the highest-density CNWs with a wall-to-wall distance of 142 nm. The laser desorption/ionization effect of arginine, an amino acid, was also investigated. When CNWs with a narrower wall-to-wall distance were used, the signal-to-noise (SN) ratios of the arginine signals were increased, while the intensity ratios of fragment ions to arginine signals were suppressed. Therefore, the CNWs nanostructures are a powerful tool when used as a SALDI substrate for the highly efficient desorption/ionization of low-molecular-weight biomolecules.

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