Journal
MOLECULAR THERAPY-NUCLEIC ACIDS
Volume 23, Issue -, Pages 918-929Publisher
CELL PRESS
DOI: 10.1016/j.omtn.2021.01.002
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Funding
- National Natural Science Foundation of China [81972663, 81560385]
- Key Scientific Research Projects of Institutions of Higher Education in Henan Province [19A310024]
- Medical Scientific and Technological Research Project of Henan Province [201702027]
- Youth Innovation Fund Project of The First Affiliated Hospital of Zhengzhou University [YNQN2017035]
- China Postdoctoral Science Foundation [2019T120648, 2017M610462]
- National Natural Science Foundation of Henan Province [182300410342]
- Health Commission Technology Talents Overseas Training Project of Henan Province [2018140]
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circRNAs are a type of stable noncoding RNA found mainly in the cytoplasm, playing important biological functions, especially in the process of autophagy. They can regulate gene expression, bind to RBPs, encode proteins, regulate alternative splicing, and play crucial roles in various diseases.
Circular RNAs (circRNAs) are a type of special noncoding RNA. circRNAs are highly stable and are found mainly in the cytoplasm. Most circRNAs are conserved and usually exhibit tissue specificity and timing specificity. In addition to the regulation mode of competitive endogenous RNA (ceRNA), circRNAs can also bind to RNA-binding proteins (RBPs), regulate alternative splicing, encode proteins or polypeptides, and regulate the expression of parent genes affecting biological pathways in which coded proteins are involved. Autophagy is an important cellular mechanism that plays an essential role in normal cell physiological processes and in diseases, especially tumors. Studies reported that circRNAs have an important effect on autophagic processes. What are the detailed biological functions and mechanisms of circRNAs in autophagy? In this article, we summarize the relationship between circRNAs and autophagy and the regulatory function and mechanism (especially as microRNA [miRNA] sponges and binding to RBPs) of circRNAs in autophagy. In addition, we discuss the dysregulation and functional and clinical applications of autophagy-associated circRNAs in a variety of diseases. Autophagy-associated circRNAs have the potential to be essential biomarkers of diagnosis and treatment and to be beneficial to the research and development of targeted drugs for tumor or non-tumor diseases.
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