Journal
MOLECULAR THERAPY-NUCLEIC ACIDS
Volume 23, Issue -, Pages 887-896Publisher
CELL PRESS
DOI: 10.1016/j.omtn.2020.12.021
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Funding
- National Natural Science Foundation of China [81871871, 81902333]
- Key Research and Development Plan (Social Development) of Science and Technology Department of Jiangsu Province [BE2019760]
- Medical Innovation Team Foundation of the Jiangsu Provincial Enhancement Health Project [CXTDA2017021]
- Postgraduate Research AMP
- Practice Innovation Program of Jiangsu Province [KYCX19_1170]
- Second Affiliated Hospital of Nanjing Medical University [789ZYRC202090146]
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m(6)A is a modification of eukaryotic RNA that is dynamically regulated during cell metabolism and embryo development, mainly involved in various aspects of RNA metabolism, and closely related to the occurrence and development of cancer. Methyltransferases, as key elements in the dynamic regulation of m(6)A, play a crucial role in these processes.
Modification of eukaryotic RNA by methylation of adenosine residues to generate N-6-methyladenosine (m(6)A) is a highly prevalent process. m(6)A is dynamically regulated during cell metabolism and embryo development, and it is mainly involved in various aspects of RNA metabolism, including RNA splicing, processing, transport from the nucleus, translation, and degradation. Accumulating evidence shows that dynamic changes to m(6)A are closely related to the occurrence and development of cancer and that methyltransferases, as key elements in the dynamic regulation of m(6)A, play a crucial role in these processes. Therefore, in this review, we describe the role of methyltransferases as m(6)A writers in cancer and summarize their potential molecular mechanisms of action.
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