4.6 Article

COVID-19 Disease Course in Former Smokers, Smokers and COPD Patients

Journal

FRONTIERS IN PHYSIOLOGY
Volume 11, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2020.637627

Keywords

SARS-CoV-2; COVID-19; infection; smoking; chronic obstructive pulmonary disease

Categories

Funding

  1. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [19/02679-7, 17/18199-9]
  2. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES [88887.503842/2020-00]
  3. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/18199-9] Funding Source: FAPESP

Ask authors/readers for more resources

COVID-19, caused by SARS-CoV-2, is a severe respiratory and systemic disease posing a huge global challenge. Risk factors for disease severity include systemic arterial hypertension, diabetes, obesity, older age, and other infections. Smoking and COPD, common comorbidities in COVID-19 patients, may increase inflammation markers during the disease course, suggesting their role as risk factors for severe COVID-19.
The severe respiratory and systemic disease named coronavirus disease-2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, the COVID-19 pandemic presents a huge social and health challenge worldwide. Many different risk factors are associated with disease severity, such as systemic arterial hypertension, diabetes mellitus, obesity, older age, and other co-infections. Other respiratory diseases such as chronic obstructive pulmonary disease (COPD) and smoking are common comorbidities worldwide. Previous investigations have identified among COVID-19 patients smokers and COPD patients, but recent investigations have questioned the higher risk among these populations. Nevertheless, previous reports failed to isolate smokers and COPD patients without other comorbidities. We performed a longitudinal evaluation of the disease course of smokers, former smokers, and COPD patients with COVID-19 without other comorbidities, from hospitalization to hospital discharge. Although no difference between groups was observed during hospital admission, smokers and COPD patients presented an increase in COVID-19-associated inflammatory markers during the disease course in comparison to non-smokers and former smokers. Our results demonstrated that smoking and COPD are risk factors for severe COVID-19 with possible implications for the ongoing pandemic.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available