Journal
FRONTIERS IN PHARMACOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2020.617843
Keywords
oxidative stress; natural antioxidants; anti-ovarian aging; reactive oxygen species; mitochondria; inflammation; apoptosis; telomeres
Categories
Funding
- Zhejiang Provincial TCM Sci-tech Plan [2020ZA078]
- Zhejiang Zhangqin famous Traditional Chinese Medicine expert inheritance studio project [GZS2012014]
- Medical and health science and technology plan of Zhejiang Province [2021KY920]
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Oxidative stress plays a role in ovarian aging and contributes to the development of other related etiologies. Natural antioxidants like quercetin, resveratrol, and curcumin have a protective role in the ovaries through multiple mechanisms, suggesting their potential as therapeutic interventions for delaying ovarian aging.
The ovarian system comprises vital organs in females and is of great significance for the maintenance of reproductive potential and endocrine stability. Although complex pathogenesis undoubtedly contributes to ovarian aging, increasing attention is being paid to the extensive influence of oxidative stress. However, the role of oxidative stress in ovarian aging is yet to be fully elucidated. Exploring oxidative stress-related processes might be a promising strategy against ovarian aging. In this review, compelling evidence is shown that oxidative stress plays a role in the etiology of ovarian aging and promotes the development of other ovarian aging-related etiologies, including telomere shortening, mitochondrial dysfunction, apoptosis, and inflammation. In addition, some natural antioxidants such as quercetin, resveratrol, and curcumin have a protective role in the ovaries through multiple mechanisms. These findings raise the prospect of oxidative stress modulator-natural antioxidants as therapeutic interventions for delaying ovarian aging.
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