Journal
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
Volume 14, Issue 2, Pages 239-248Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17512433.2021.1878877
Keywords
TanshinoneIIa; endothelial cells; monomeric compound; oxidative stress; inflammatory injury
Categories
Ask authors/readers for more resources
Tanshinone IIa (TSA) extracted from Danshen has been approved to treat cardiovascular diseases and has shown pharmacological effects such as vasodilation, antioxidant, anti-inflammatory, and anti-tumor properties. Studies have shown that TSA can improve endothelial cell function through various pathways, suggesting its potential for early disease diagnosis and development of precise therapeutic methods for endothelial cell injury.
Introduction Tanshinone IIa (TSA) has been approved to treat cardiovascular diseases by the China State Food and Drug Administration. TSA has exhibited a variety of pharmacological effects, including vasodilator, antioxidant, anti-inflammatory, and anti-tumor properties. Endothelial cells play an important physiological role in vascular homeostasis and control inflammation, coagulation, and thrombosis. Accumulating studies have shown that TSA can improve endothelial function through various pathways. Areas covered The PubMed database was reviewed for relevant papers published up to 2020. This review summarizes the current clinical and pharmaceutical studies to provide a systemic overview of the pharmacological and therapeutic effects of TSA on endothelial cells. Expert opinion TSA is a representative monomeric compound extracted from Danshen and it exhibits significant pharmacological and therapeutic properties to improve endothelial cell function, including alleviating oxidative stress, attenuating inflammatory injury, modulating ion channels and so on. TSA represents a spectrum of agents that are extracted from plants and can restore the endothelial function to establish the beneficial and harmless molecular therapeutics. This also suggests the possible detection of endothelial cells for very early diagnosis of diseases. In future, precise therapeutic methods will be developed to repair endothelial cells injury and recover endothelial dysfunction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available