4.7 Article

Emergence and spread of novel H5N8, H5N5 and H5N1 clade 2.3.4.4 highly pathogenic avian influenza in 2020

Journal

EMERGING MICROBES & INFECTIONS
Volume 10, Issue 1, Pages 148-151

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2021.1872355

Keywords

Influenza; emergence; HPAI; Eurasia; avian

Funding

  1. Erasmus MC - NIAID/NIH [HHSN272201400008C]
  2. U.K. Department for Environment, Food, and Rural Affairs (Defra)
  3. Scottish Government
  4. Welsh Government [SV3006]
  5. APHA
  6. OIE [OR1078]

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Analyses of highly pathogenic H5 viruses from poultry outbreaks across a wide Eurasian region since July 2020, including the Russian Federation, Republics of Iraq and Kazakhstan, and recent detections in migratory waterfowl in the Netherlands, revealed a variety of H5Nx subtypes posing a threat to poultry production, food security and veterinary public health.
Analyses of HPAI H5 viruses from poultry outbreaks across a wide Eurasian region since July 2020 including the Russian Federation, Republics of Iraq and Kazakhstan, and recent detections in migratory waterfowl in the Netherlands, revealed undetected maintenance of H5N8, likely in galliform poultry since 2017/18 and both H5N5 and H5N1. All viruses belong to A/H5 clade 2.3.4.4b with closely related HA genes. Heterogeneity in Eurasian H5Nx HPAI emerging variants threatens poultry production, food security and veterinary public health.

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