Conservative Therapy for Peyronie's Disease: a Contemporary Review of the Literature

Purpose of Review To analyze the literature on current conservative treatment options for Peyronie's disease (PD). Recent indings Conservative therapy with intralesional collagenase clostridium histolyticum (CCH) is safe and efficacious in either the acute or chronic phases of PD. Combination treatment with penile traction therapy (PTT) can produce even better results. While most PTT devices require extended periods of therapy up to 8 h per day, the RestoreX (R) device can be effective at 30-90 min per day. Summary A variety of conservative therapies are available for treatment of PD. The available literature does not reveal any treatment benefit of oral therapies. Intralesional therapy is the mainstay conservative treatment of PD. Intralesional CCH therapy is the first Food and Drug Administration-approved intralesional therapy and represents the authors' preference for medical therapy. The most effective conservative management of PD likely requires a combination of therapies.

Automated summary

Conservative treatment options for Peyronie's disease include intralesional collagenase clostridium histolyticum (CCH) and penile traction therapy (PTT), which have been shown to be safe and effective. Intralesional therapy is the mainstay treatment, with a combination of therapies likely to be the most effective approach.