Journal
CANCER MEDICINE
Volume 10, Issue 2, Pages 642-648Publisher
WILEY
DOI: 10.1002/cam4.3648
Keywords
acute myeloid leukemia; FLT3 ligand; IL‐ 6; prognostic biomarker
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Funding
- DHU Oncogreffe of Nantes
- LHEMA/Nantes University Hospital
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This study aimed to assess the potential impact of serum cytokines kinetics during induction in AML patients and proposed a new risk stratification based on the kinetic profiles of FL and IL-6 to predict survival outcomes.
The aim of this study was to assess the potential impact of the kinetics of serum levels of seven cytokines during induction in acute myeloid leukemia (AML) patients. Indeed, the role of cytokines, in the pathophysiology and response to therapy of AML patients, remains under investigation. Here, we report on the impact of peripheral levels of two cytokines, the Fms-like tyrosine kinase 3 ligand (FL) and interleukin-6 (IL-6), evaluated during first-line intensive induction. A new risk stratification can be proposed, which supersedes the ELN 2017 classification to predict survivals in AML patients by examining the kinetic profile of these cytokines during the induction phase. It segregates three groups of, respectively, high-risk, characterized by a stagnation of low FL levels, intermediate risk, with dynamic increasing FL levels and high IL-6 at day 22, and favorable risk with increasing FL levels but low IL-6 at day 22.
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