Carvone suppresses oxidative stress and inflammation in the liver of immobilised rats

Objective The investigation of the effect of carvone (a natural monoterpene) on liver damage caused by chronic immobilisation. Methods Male Wistar rats were divided into four groups: control, carvone, stress, and stress-carvone. To induce stress, rats were placed in a restrainer (6 h/21 day) and carvone was treated by gavage at a dose of 20 mg/kg. Results Alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase activities were significantly increased in sera of immobilised rats. Chronic immobilisation also increased malondialdehyde levels and decreased reduced glutathione content, as well as increased TNF-alpha, IL-1 beta, IL-6, and NF-kappa B mRNA expression and also led to the infiltration of inflammatory cells in the liver parenchyma. Carvone's 21-day treatment prevented all of these changes in immobilised rats. Conclusion It is concluded that carvone has effectively prevented chronic immobilisation-induced liver injury, most probably through its antioxidant and anti-inflammatory capabilities.

Automated summary

Carvone has been found to have antioxidant and anti-inflammatory effects on liver damage caused by chronic immobilisation.