Journal
TRANSLATIONAL PSYCHIATRY
Volume 10, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41398-020-01109-5
Keywords
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Categories
Funding
- European Research Council (ERC) under the European Union [671084 -INSOMNIA]
- VU University Amsterdam University Research Fellowships
- NIH Consortium grant [U54 EB020403, R01 MH116147, P41 EB015922, R01 MH117601]
- Spanish Ministry of Health [CP16-00020]
- Wellcome Trust [104036/Z/14/Z]
- European Community [602450]
- Wellcome Trust Strategic Award [104036/Z/14/Z]
- IMAGEMEND grant
- Branch Out Neurological Foundation, Children's Hospital Aid Society
- Science Foundation Ireland (SFI) Professorship grant
- German Research Foundation (DFG) [FOR2107 KR 3822/5-1, KR 3822/7-2, FOR2107 KI 588/14-1, KI 588/14-2, FOR2107 NE 2254/1-2, FOR2107 DA1151/5-1, DA1151/5-2]
- NIMH grant [R01 085667]
- Dunn Foundation
- Pat Rutherford, Jr. Endowed Chair in Psychiatry
- German Research Foundation [SFB-TRR58]
- Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster [Dan3/012/17]
- Optimising Personalised Care, at scale, for Young People with Emerging Mood Disorders [APP1136259]
- Russian Science Foundation [16-15-00128]
- UK Medical Research Council [G0701421]
- NIMH [R01-MH59259, R37MH101495]
- NIA [T32AG058507]
- NIH/NIMH [5T32MH073526]
- NIH from the Big Data to Knowledge (BD2K) Program [U54EB020403]
- Wellcome Trust Strategic Award STratifying Resilience and Depression Longitudinally (STRADL) [104036/Z/14/Z]
- Alberta Children's Hospital Research Institute
- Exzellenz-Stiftung of the Max Planck Society
- Federal Ministry of Education and Research (BMBF) [FKZ 01GS0481]
- Innovative Medical Research [RE111604, RE111722]
- Sogen-sha
- Dr Mortimer and Theresa Sackler Foundation
- [PI13/01057]
- [1U54MH091657]
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It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts within the ENIGMA MDD Working Group. Insomnia severity was measured by summing the insomnia items of the Hamilton Depression Rating Scale (HDRS). Symptom specificity was evaluated with correlates of overall depression severity. Disease specificity was evaluated in two independent samples comprising 2108 healthy controls, and in 260 clinical controls with bipolar disorder. Results showed that MDD patients with more severe insomnia had a smaller cortical surface area, mostly driven by the right insula, left inferior frontal gyrus pars triangularis, left frontal pole, right superior parietal cortex, right medial orbitofrontal cortex, and right supramarginal gyrus. Associations were specific for insomnia severity, and were not found for overall depression severity. Associations were also specific to MDD; healthy controls and clinical controls showed differential insomnia severity association profiles. The findings indicate that MDD patients with more severe insomnia show smaller surfaces in several frontoparietal cortical areas. While explained variance remains small, symptom-specific associations could bring us closer to clues on underlying biological phenomena of MDD.
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