Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi

Two new (1-2) and three known (3-5) sorbicillinoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi MCCC 3A00580. Compounds 1 and 2, named sorbicatechols C and D, were two new hybrid dihydrosorbillinoids. Their structures were established mainly by spectroscopic analyses and electronic circular dichroism (ECD) calculations. All five isolates were tested for antiproliferative activities against four tumor cell lines of MCF-7, HT-29, HuH-7, and LNCap. Compounds 2 and 5 inhibited HT-29 cells in a good dose-dependent manner. Mechanism investigation uncovered that they could significantly induce cell cycle G2-M phase arresting by increasing the protein levels of p-H3 and cyclin B1.

Automated summary

Two new sorbicillinoids, sorbicatechols C and D, were isolated from the deep-sea-derived fungus Penicillium allii-sativi MCCC 3A00580, along with three known compounds. These compounds showed antiproliferative activities against tumor cell lines, particularly inducing cell cycle G2-M phase arrest.