Role of Lactobacillus in Female Infertility Via Modulating Sperm Agglutination and Immobilization

Infertility has become a common problem in recent decades. The pathogenesis of infertility is variable, but microbiological factors account for a large proportion of it. Dysbiosis of vaginal microbiota is reportedly associated with female infertility, but the influence of normal vaginal microbiota on infertility is unclear. In this review, we summarize the physiological characteristics of the vaginal tract and vaginal microbiota communities. We mainly focus on the bacterial adherence of vaginal Lactobacillus species. Given that the adherent effect plays a crucial role in the colonization of bacteria, we hypothesize that the adherent effect of vaginal Lactobacillus may also influence the fertility of the host. We also analyze the agglutination and immobilization effects of other bacteria, especially Escherichia coli, on ejaculated spermatozoa, and speculate on the possible effects of normal vaginal microbiota on female fertility.

Automated summary

Infertility has become a common issue in recent decades, with microbiological factors playing a significant role. Dysbiosis of vaginal microbiota is linked to female infertility, but the impact of normal vaginal microbiota on fertility remains unclear. This review focuses on the bacterial adherence of vaginal Lactobacillus species, hypothesizing its potential influence on host fertility, and also examines the effects of other bacteria, especially Escherichia coli, on ejaculated spermatozoa.