Electrolyte-Triggered C5-Selective Trifluoromethylation and Halogenation of 8-Aminoquinoline Derivatives

An efficient electrolyte-triggered trifluoromethylation and halogenation at C5 position of 8-aminoquinoline derivatives was developed, affording the C-H functionalization products in moderate to excellent yields. Furthermore, the mild and green reactions had lower energy consumption and shorter times. Most importantly, both transition-metal catalysts and oxidants were avoided.

Automated summary

An efficient electrolyte-triggered trifluoromethylation and halogenation at C5 position of 8-aminoquinoline derivatives was developed, giving moderate to excellent yields of C-H functionalization products. The mild and green reactions had lower energy consumption and shorter reaction times, while avoiding the use of transition-metal catalysts and oxidants.