Continuous-Flow Production of Isosorbide from Aqueous-Cellulosic Derivable Feed over Sustainable Heterogeneous Catalysts

Continuous-flow sorbitol dehydration in liquid water was performed on beta zeolite (Si/Al molar ratio = 75) with conversion of 94 and 83 mol % isosorbide yield. This efficiency is due to the three-dimension pore architecture, high specific surface area (520 m(2) g(-1)), and Bronsted acid sites of 69 mu mol g(-1). The pore size of beta zeolite (6.6 x 6.7 angstrom(2)) is slightly larger than the cross section of sorbitol and isosorbide and enables an efficient diffusion of the reactant and product to/from the pores. Operation in continuous flow allows rapid dehydration of sorbitol to 1,4-sorbitan, after which the latter got converted to isosorbide. The high yield of isosorbide is attributed to the continuous removal of the formed products from the catalyst surface. Finally, direct isosorbide production from aqueous glucose solution via hydrogenation on Ni catalyst supported on nitrogen-doped carbon, followed by dehydration of the formed sorbitol to isosorbide, was pioneered.

Automated summary

Continuous-flow sorbitol dehydration on beta zeolite in liquid water resulted in efficient isosorbide yield. The excellent pore structure and acidity of beta zeolite enable efficient reaction and diffusion. Operation in continuous flow allowed for high isosorbide yield.