4.6 Article

Novel Biobased Furanic Diols as Potential Alternatives to BPA: Synthesis and Endocrine Activity Screening

Journal

ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 8, Issue 51, Pages 18824-18829

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.0c08207

Keywords

Furanic diols; Bisphenol A replacement; Biomass; 5-Hydroxymethyl furfural; Endocrine activity

Funding

  1. National Science Foundation [IIA-1355466]
  2. AkzoNobel
  3. Center for Biobased Materials Science and Technology, a North Dakota Center of Research Excellence

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A series of asymmetric and symmetric diols were prepared in high yields from biomass-derived feedstocks 5-hydroxymethyl furfural (HMF) and 2,5-diformyl furan (DFF) as potential replacements for bisphenol A (BPA). The diols were screened for estrogenic, androgenic, antiandrogenic, and antithyroid activities in reporter gene assays. Several of the low molecular weight asymmetric diols did not exhibit activity in any of the assays and thus have promise as potentially more sustainable alternatives to BPA.

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