Journal
TOXINS
Volume 13, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/toxins13010050
Keywords
nicotinamide; CKD; NAD(+); adenine-induced CKD model; glycolysis; Krebs cycle
Categories
Funding
- JSPS KAKENHI [19K08669]
- Miyagi Renal Association Research Grant
- Koyanagi Foundation
- Grants-in-Aid for Scientific Research [19K08669] Funding Source: KAKEN
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NAD(+) plays a crucial role in kidney disease by promoting ATP generation for energy oxidation and anti-inflammatory reactions. Supplementation of the NAD(+) precursor nicotinamide can reduce kidney inflammation and fibrosis, potentially preventing disease progression.
Nicotinamide adenine dinucleotide (NAD(+)) supplies energy for deoxidation and anti-inflammatory reactions fostering the production of adenosine triphosphate (ATP). The kidney is an essential regulator of body fluids through the excretion of numerous metabolites. Chronic kidney disease (CKD) leads to the accumulation of uremic toxins, which induces chronic inflammation. In this study, the role of NAD(+) in kidney disease was investigated through the supplementation of nicotinamide (Nam), a precursor of NAD(+), to an adenine-induced CKD mouse model. Nam supplementation reduced kidney inflammation and fibrosis and, therefore, prevented the progression of kidney disease. Notably, Nam supplementation also attenuated the accumulation of glycolysis and Krebs cycle metabolites that occurs in renal failure. These effects were due to increased NAD(+) supply, which accelerated NAD(+)-consuming metabolic pathways. Our study suggests that Nam administration may be a novel therapeutic approach for CKD prevention.
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