4.7 Review

Targeting the alternative bile acid synthetic pathway for metabolic diseases

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility

Meilin Wei et al.

EBIOMEDICINE (2020)

Article Biochemistry & Molecular Biology

Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta

Emma M. Lofthouse et al.

FASEB JOURNAL (2019)

Article Pharmacology & Pharmacy

Ursodeoxycholic acid accelerates bile acid enterohepatic circulation

Yunjing Zhang et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Mitochondrial oxysterol biosynthetic pathway gives evidence for CYP7B1 as controller of regulatory oxysterols

Gents Kakiyama et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

Article Medical Laboratory Technology

Tissue and serum metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma

Jun Han et al.

CLINICA CHIMICA ACTA (2019)

Review Gastroenterology & Hepatology

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Wei Jia et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Article Oncology

Tumor LXR Expression is a Prognostic Marker for Patients with Hepatocellular Carcinoma

Houyong Long et al.

PATHOLOGY & ONCOLOGY RESEARCH (2018)

Review Pharmacology & Pharmacy

Progress and challenges of selective Farnesoid X Receptor modulation

Vittoria Massafra et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Article Pharmacology & Pharmacy

The gut-liver axis in hepatocarcinoma: a focus on the nuclear receptor FXR and the enterokine FGF19

Marilidia Piglionica et al.

CURRENT OPINION IN PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Bile salt hydrolases: Structure and function, substrate preference, and inhibitor development

Zixing Dong et al.

PROTEIN SCIENCE (2018)

Review Biochemistry & Molecular Biology

Bile acid analysis in human disorders of bile acid biosynthesis

Frederic. M. Vaz et al.

MOLECULAR ASPECTS OF MEDICINE (2017)

Article Biochemistry & Molecular Biology

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

Berengere Benoit et al.

NATURE MEDICINE (2017)

Article Endocrinology & Metabolism

Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption

Enrico Bertaggia et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2017)

Review Oncology

Cholesterol metabolites and tumor microenvironment: the road towards clinical translation

Laura Raccosta et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)

Review Biotechnology & Applied Microbiology

Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

Chiara Degirolamo et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Cell & Tissue Engineering

Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver

Valgardur Sigurdsson et al.

CELL STEM CELL (2016)

Editorial Material Cell & Tissue Engineering

EnaBILEing Growth in the Fetal Liver

Wolfram Goessling et al.

CELL STEM CELL (2016)

Review Medicine, General & Internal

The gut microbiota and metabolic disease: current understanding and future perspectives

T. Arora et al.

JOURNAL OF INTERNAL MEDICINE (2016)

Article Biochemistry & Molecular Biology

Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol

Jiwei Li et al.

JOURNAL OF LIPID RESEARCH (2016)

Article Chemistry, Analytical

Bile acid profiles in diabetic (db/db) mice and their wild type littermates

Chang Chen et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2016)

Review Biochemistry & Molecular Biology

Oxysterols: From cholesterol metabolites to key mediators

Valentin Mutemberezi et al.

PROGRESS IN LIPID RESEARCH (2016)

Review Biochemistry & Molecular Biology

Oxysterols in Metabolic Syndrome: From Bystander Molecules to Bioactive Lipids

Owein Guillemot-Legris et al.

TRENDS IN MOLECULAR MEDICINE (2016)

Review Cell Biology

Uncoupling Nuclear Receptor LXR and Cholesterol Metabolism in Cancer

Fabiola Bovenga et al.

CELL METABOLISM (2015)

Article Cell Biology

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

Evie P. M. Broeders et al.

CELL METABOLISM (2015)

Article Biochemistry & Molecular Biology

Oxysterol-binding Protein-related Protein 8 (ORP8) Increases Sensitivity of Hepatocellular Carcinoma Cells to Fas-Mediated Apoptosis

Wenbin Zhong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Endocrinology & Metabolism

Chenodeoxycholic Acid as a Potential Prognostic Marker for Roux-en-Y Gastric Bypass in Chinese Obese Patients

Haoyong Yu et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Biochemistry & Molecular Biology

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Sungsoon Fang et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Mohamed-Sami Trabelsi et al.

NATURE COMMUNICATIONS (2015)

Article Endocrinology & Metabolism

Loss of Cyp8b1 Improves Glucose Homeostasis by Increasing GLP-1

Achint Kaur et al.

DIABETES (2015)

Article Biochemistry & Molecular Biology

SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma

Chao Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Review Gastroenterology & Hepatology

Bile acid receptors as targets for drug development

Frank G. Schaap et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)

Article Obstetrics & Gynecology

Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study

E. Wikstroem Shemer et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2013)

Review Cell Biology

Pleiotropic Roles of Bile Acids in Metabolism

Thomas Q. de Aguiar Vallim et al.

CELL METABOLISM (2013)

Article Endocrinology & Metabolism

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12a-Hydroxylated Bile Acids

Rebecca A. Haeusler et al.

DIABETES (2013)

Article Immunology

The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils

Laura Raccosta et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Review Cell Biology

Oxysterol generation and liver X receptor-dependent reverse cholesterol transport: Not all roads lead to Rome

Parveer S. Pannu et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2013)

Article Pharmacology & Pharmacy

Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

April D. Lake et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)

Article Cell Biology

A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth

Ming Lu et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2013)

Article Endocrinology & Metabolism

25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages

Leyuan Xu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

Article Gastroenterology & Hepatology

Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease

Tadashi Ikegami et al.

JOURNAL OF GASTROENTEROLOGY (2012)

Review Multidisciplinary Sciences

Host-Gut Microbiota Metabolic Interactions

Jeremy K. Nicholson et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

Suppression of ABCA1 by unsaturated fatty acids leads to lipid accumulation in HepG2 cells

Yanhong Yang et al.

BIOCHIMIE (2010)

Review Endocrinology & Metabolism

Acyl-coenzyme A: cholesterol acyltransferases

Ta-Yuan Chang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

Article Gastroenterology & Hepatology

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

Francisco Caballero et al.

JOURNAL OF HEPATOLOGY (2009)

Review Biochemistry & Molecular Biology

Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis

Andrew J. Brown et al.

MOLECULAR ASPECTS OF MEDICINE (2009)

Review Gastroenterology & Hepatology

Bile acids: Chemistry, physiology, and pathophysiology

Maria J. Monte et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2009)

Article Biochemistry & Molecular Biology

Hepatic insulin resistance directly promotes formation of cholesterol gallstones

Sudha B. Biddinger et al.

NATURE MEDICINE (2008)

Article Biochemistry & Molecular Biology

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

Insook Kim et al.

JOURNAL OF LIPID RESEARCH (2007)

Article Biochemistry & Molecular Biology

Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes

Shunlin Ren et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Review Biochemistry & Molecular Biology

Bile salt biotransformations by human intestinal bacteria

JM Ridlon et al.

JOURNAL OF LIPID RESEARCH (2006)

Article Gastroenterology & Hepatology

Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse

DQH Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)

Article Multidisciplinary Sciences

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

BA Laffitte et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Gastroenterology & Hepatology

Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation

GL Su

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)

Article Biochemical Research Methods

Analysis of theaflavins in biological fluids using liquid chromatography-electrospray mass spectrometry

TPJ Mulder et al.

JOURNAL OF CHROMATOGRAPHY B (2001)

Article Obstetrics & Gynecology

Hepatic taurine, glycine and individual bile acids an early human fetus

S Itoh et al.

EARLY HUMAN DEVELOPMENT (2000)