Journal
POLYMERS
Volume 13, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/polym13010053
Keywords
mesoporous silica; calcium orthophosphates; hydroxyapatite; composites; rapid coating; simulated body fluid; mineralization
Categories
Funding
- project OPUS 15 [2018/29/B/NZ7/00533]
- National Science Centre
- European Union through the European Social Fund under the Operational Programme Knowledge Education Development 2014-2020 [POWR.03.02.00-00-I026/17-00]
- Financial Assistance Program for the active scientists of MUG [ZZ/KAP/00024/08/2020]
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The microwave-assisted wet precipitation method was used to prepare materials consisting of mesoporous silica and calcium orthophosphates. Different types of calcium orthophosphates were formed on the silica surface depending on the calcification coating solution, and pharmaceutical forms with retained mineralization properties were successfully produced.
Herein, the microwave-assisted wet precipitation method was used to obtain materials consisting of mesoporous silica (SBA-15) and calcium orthophosphates (CaP). Composites were prepared through immersion of mesoporous silica in different calcification coating solutions and then exposed to microwave radiation. The composites were characterized in terms of molecular structure, crystallinity, morphology, chemical composition, and mineralization potential by Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), and scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM-EDX). The application of microwave irradiation resulted in the formation of different types of calcium orthophosphates such as calcium deficient hydroxyapatite (CDHA), octacalcium phosphate (OCP), and amorphous calcium phosphate (ACP) on the SBA-15 surface, depending on the type of coating solution. The composites for which the progressive formation of hydroxyapatite during incubation in simulated body fluid was observed were further used in the production of final pharmaceutical forms: membranes, granules, and pellets. All of the obtained pharmaceutical forms preserved mineralization properties.
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