Journal
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
Volume 131, Issue 4, Pages 428-434Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.oooo.2020.12.020
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This study evaluated the efficacy of topical curcumin gel and buccal mucoadhesive patches in managing oral submucous fibrosis (OSMF), finding both treatments effective in improving mouth opening and reducing burning sensation in patients. LDH levels were significantly higher in OSMF patients compared to healthy controls, but decreased after treatment with both curcumin gel and mucoadhesive patches.
Objective. The objective of this study was to evaluate and compare the efficacy of topical curcumin gel and buccal mucoadhesive patches in the management of oral submucous fibrosis (OSMF). Study Design. Forty patients clinically diagnosed with OSMF were randomly divided into 2 groups. Group A received curcumin gel and group B received curcumin mucoadhesive patches, to be used twice daily for 8 weeks. Evaluation was done every 2 weeks. Serum lactate dehydrogenase (LDH) levels were measured before and after treatment and also in 20 healthy controls. Results. A 100% reduction in burning sensation was observed in all 40 patients at the end of 4 weeks. Mouth opening improved by 5.45 +/- 1.64 mm in group A and 5.9 +/- 2.00 mm in group B. Pretreatment LDH was 359.72 +/- 77.02 IU/L in patients with OSMF, which was significantly higher than that in healthy volunteers (173.2 +/- 46.20 IU/L). In group A, LDH values reduced from 341.85 +/- 71 IU/L to 264.95 +/- 65.09 IU/L and in group B, values reduced from 377.6 +/- 79.76 IU/L to 286.15 +/- 72.95 IU/L after treatment. Conclusion. Curcumin gel and mucoadhesive patches were effective in improving mouth opening and reducing burning sensation in patients with OSMF. They can therefore be considered as safe, noninvasive modalities for treatment of OSMF.
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