Journal
CELL REPORTS
Volume 33, Issue 10, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2020.108434
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Funding
- Indie-gogo
- Lawrence Berkeley National Laboratory Innovation grant [DEAC02-05CH11231]
- NIH/NIAID/Columbia University pilot grant [S U19 AI067773-10]
- NASA Human Research Project [NNJ16HP24I]
- Translational Research Institute for Space Health through NASA [NNX16AO69A]
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Deep space exploration will require real-time, minimally invasive monitoring of astronaut health to mitigate the potential health impairments caused by space radiation and microgravity. Genotoxic stress in humans can be monitored by quantifying the amount of DNA double-strand breaks (DSBs) in immune cells from a simple finger prick. In a cohort of 674 healthy donors, we show that the endogenous level of DSBs increases with age and with latent cytomegalovirus infection. To map the range of human responses to space radiation, we then study DSB induction and repair in immune cells from 319 healthy donors after the cells are exposed to galactic cosmic ray components and lymphocytes from 30 cancer patients after radiotherapy. Individuals with low baseline DSB have fewer clinical complications, enhanced DNA damage repair responses, and a functional dose-dependent cytokine response in healthy donor cells. This supports the use of DSB monitoring for health resilience in space.
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