Journal
CELL REPORTS
Volume 33, Issue 9, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2020.108463
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Funding
- European Union [291734]
- Swiss National Funds [31003A_165877]
- Ministry of Education, Youth, and Sports of the Czech Republic [CZ.02.1.01/0.0/0.0/16_019/0000738]
- EU Operational Programme ``Research
- (Centre for Plant Experimental Biology'')
- EU Operational Programme Prague -Competitiveness [CZ.2.16/3.1.00/21519]
- European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship [ALTF 723-2015]
- China Scholarship Council
- [PIN2-GFP]
- Swiss National Science Foundation (SNF) [31003A_165877] Funding Source: Swiss National Science Foundation (SNF)
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The widely used non-steroidal anti-inflammatory drugs (NSAIDs) are derivatives of the phytohormone salicylic acid (SA). SA is well known to regulate plant immunity and development, whereas there have been few reports focusing on the effects of NSAIDs in plants. Our studies here reveal that NSAIDs exhibit largely overlapping physiological activities to SA in the model plant Arabidopsis. NSAID treatments lead to shorter and agravitropic primary roots and inhibited lateral root organogenesis. Notably, in addition to the SA-like action, which in roots involves binding to the protein phosphatase 2A (PP2A), NSAIDs also exhibit PP2A-independent effects. Cell biological and biochemical analyses reveal that many NSAIDs bind directly to and inhibit the chaperone activity of TWISTED DWARF1, thereby regulating actin cytoskeleton dynamics and subsequent endosomal trafficking. Our findings uncover an unexpected bioactivity of human pharmaceuticals in plants and provide insights into the molecular mechanism underlying the cellular action of this class of anti-inflammatory compounds.
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