Journal
ALZHEIMERS RESEARCH & THERAPY
Volume 12, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13195-020-00734-y
Keywords
Subjective cognitive decline; Prevalence; Epidemiology; Individual participant data; Data harmonization; Cohort study
Categories
Funding
- LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig - European Social Fund
- Free State of Saxony [LIFE-103 P1]
- Hans and Ilse Breuer Foundation
- National Health and Medical Research Council of Australia [1093083, 973302, 179805, 157125, 1002160]
- National Institute On Aging of the National Institutes of Health [RF1AG057531]
- Dementia Momentum Fund (UNSW) [PS38235]
- Medical Research Council
- Department of Health, UK
- National Institutes of Health grants NIA [2 P01 AG03949]
- Leonard and Sylvia Marx Foundation
- Czap Foundation
- French National Research Agency [ANR-09-MNPS-009-01]
- Novartis
- Federazione Alzheimer Italia, Milan, Italy
- Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea [HI09C1379 (A092077)]
- Interdisciplinary Centre for Clinical Research at the University of Leipzig (Interdisziplinares Zentrum fur Klinische Forschung/IZKF) [01KS9504]
- Ministry of Education Longterm Research Grant Scheme [LRGS/BU/2012/UKMUKM/K/01]
- Netherlands Organization for Scientific Research (NOW) [002.005.019]
- National Institute on Aging, National Institutes of Health, United States Department of Health and Human Services [R01AG07562]
- JSPS KAKENHI [JP17K09146]
- Agency for Science Technology and Research (A*STAR) Biomedical Research Council (BMRC) [03/1/21/17/214, 08/1/21/19/567]
- National Medical Research Council [NMRC/1108/2007]
- Fondo de Investigacion Sanitaria
- Instituto de Salud Carlos III
- Spanish Ministry of Economy and Competitiveness, Madrid, Spain [94/1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, G03/128]
- Fondo Europeo de Desarrollo Regional (FEDER) of the European Union
- Gobierno de Aragon [19]
- Projekt DEAL
Ask authors/readers for more resources
Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available