4.7 Article

Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening

Journal

SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -

Publisher

NATURE RESEARCH
DOI: 10.1038/s41598-020-79813-x

Keywords

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Funding

  1. Spanish Ministry of Science, Innovation and Universities (MCINN) [RTI2018-095159-B-I00]
  2. Instituto de Salud Carlos III (ISCIII)-Fondo Europeo de Desarrollo Regional (FEDER) [PI18/00643]
  3. Spanish Ministry of Economy and Competitiveness (MINECO-AES)
  4. Miguel Servet contract from ISCIII-MINECO-AES-FEDER-FSE
  5. Program I2 from the Regional Government of Madrid

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Aseptic loosening involves inflammation and bone resorption processes. The study found higher serum IGFBP-1 levels in revision surgery patients compared to primary total hip arthroplasty patients, possibly due to increased local IGFBP-1 production in the inflammatory environment of the periprosthetic bed.
The biological mechanisms involved in aseptic loosening include inflammation-associated and bone resorption-associated processes. Coordinated cellular actions result in biochemical imbalances with devastating consequences for the joint. Given that this condition is not known for showing systemic signs, we investigated whether circulating levels of inflammation-related proteins are altered in patients with aseptic loosening. Our study included 37 patients who underwent revision surgery due to hip osteolysis and aseptic loosening and 31 patients who underwent primary total hip arthroplasty. Using antibody arrays, we evaluated the serum levels of 320 proteins in four patients from each group. The results showed differences in insulin-like growth factor-binding protein 1 (IGFBP-1) concentrations, which we then quantified using enzyme-linked immunosorbent assay tests in all study patients. The results confirmed that serum IGFBP-1 concentrations were higher in the revision surgery patients than in the hip arthroplasty patients. In vitro studies showed that exposure of human osteoblasts to titanium particles induced an IGFBP-1 release that further increased when exposure to particles was performed in media conditioned by human M1 macrophages. These findings suggest that elevated serum IGFBP-1 levels in patients with aseptic loosening can arise from increased local IGFBP-1 production in the inflammatory environment of the periprosthetic bed.

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