Human whole genome sequencing in South Africa

The advent and evolution of next generation sequencing has considerably impacted genomic research. Until recently, South African researchers were unable to access affordable platforms capable of human whole genome sequencing locally and DNA samples had to be exported. Here we report the whole genome sequences of the first six human DNA samples sequenced and analysed at the South African Medical Research Council's Genomics Centre. We demonstrate that the data obtained is of high quality, with an average sequencing depth of 36.41, and that the output is comparable to data generated internationally on a similar platform. The Genomics Centre creates an environment where African researchers are able to access world class facilities, increasing local capacity to sequence whole genomes as well as store and analyse the data.

Automated summary

The emergence of next generation sequencing has had a significant impact on genomic research, enabling South African researchers to access high quality data comparable to international standards at the South African Medical Research Council's Genomics Centre. This has enhanced the capacity of African researchers to sequence whole genomes and analyze data locally.