Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-020-80608-3
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Funding
- Seoul R&BD program, Republic of Korea [SS110011]
- Brain Korea 21 (BK21 FOUR)
- National Research Foundation of Korea (NRF) - Korean Government (MSIP) [NRF-2018M3C1B7020722, NRF-2019R1A2B5B01070617]
- Seoul RBD program [SS100008]
- National Research Foundation of Korea [5199991714317, 2018M3C1B7020722] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The study demonstrates the synergistic effect of releasing BMP-2 and ALN in a sequential manner for enhanced bone regeneration. By combining these two bioactive molecules, the collagen-hydroxyapatite composite scaffolds significantly increase osteogenic activity, showing potential for application in cell-free tissue engineering.
The clinical use of bioactive molecules in bone regeneration has been known to have side effects, which result from uncontrolled and supraphysiological doses. In this study, we demonstrated the synergistic effect of two bioactive molecules, bone morphogenic protein-2 (BMP-2) and alendronate (ALN), by releasing them in a sequential manner. Collagen-hydroxyapatite composite scaffolds functionalized using BMP-2 are loaded with biodegradable microspheres where ALN is encapsulated. The results indicate an initial release of BMP-2 for a few days, followed by the sequential release of ALN after two weeks. The composite scaffolds significantly increase osteogenic activity owing to the synergistic effect of BMP-2 and ALN. Enhanced bone regeneration was identified at eight weeks post-implantation in the rat 8-mm critical-sized defect. Our findings suggest that the sequential delivery of BMP-2 and ALN from the scaffolds results in a synergistic effect on bone regeneration, which is unprecedented. Therefore, such a system exhibits potential for the application of cell-free tissue engineering.
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