Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-020-80589-3
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Funding
- KAKENHI from the Japanese Society for the Promotion of Science (JSPS) [19K18552]
- Ministry of Health, Labour, and Welfare [18060798]
- Grants-in-Aid for Scientific Research [19K18552] Funding Source: KAKEN
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Electrocautery treatment for patients with Hunner type interstitial cystitis is effective but may require multiple sessions. The number of sessions and intervals between treatments impact the changes in maximum bladder capacity. Initial bladder capacity below 400 mL is a significant risk factor for subsequent MBC loss over time.
Electrocautery is a promising treatment option for patients with Hunner type interstitial cystitis (HIC), but frequently requires multiple sessions due to recurrence of the lesions. In the present study, we assessed the relationship between the frequency of electrocautery of Hunner lesions and changes in maximum bladder capacity (MBC) at hydrodistension in a large cohort of 118 HIC patients. Three mixed-effect linear regression analyses were conducted for MBC against (1) the number of sessions; (2) the number of sessions and the time between each session and the first session; and (3) other relevant clinical parameters in addition to the Model (2). The mean number of sessions was 2.8 times. MBC decreased approximately 50 mL for each additional electrocautery session, but this loss was offset by 10 mL for each year the subsequent session was postponed. MBC of<400 mL at the first session was a significant risk factor for MBC loss with further sessions. No other clinical parameters were associated with MBC over time. This study demonstrates a significant relationship between the frequency of electrocautery of Hunner lesions and MBC changes in HIC patients. Low MBC at the first session is a poor prognostic marker for MBC loss over multiple sessions.
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