Journal
SCIENTIFIC REPORTS
Volume 10, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41598-020-77783-8
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Funding
- National Natural Science Foundation of China [31871510]
- Science Foundation of Jilin Province [20180414040GH, 20200201142JC, 2016Q039]
- Department of Finance of Jilin Province [JCSZ2019378-29]
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Fibroblasts play an important role in inflammation and tissue fibrosis. Both activin A and TNF-alpha can activate immune cells, however, the roles and relationship of them in activating fibroblasts in inflammation remain unclear. Here, this study revealed that TNF-alpha promoted the release of NO and IL-6 by L929 fibroblast cells, but co-treatment with activin A attenuated these effects. In contrast, activin A induced cell migration and increased the production of tissue fibrosis-related TGF-beta 1 and fibronectin, while TNF-alpha inhibited these function changes of L929 cells induced by activin A. Moreover, this study revealed that activin A and TNF-alpha regulated the activities of L929 cells via ERK1/2/MAPK pathway, rather than Smad3-dependent signaling pathway. Taken together, these data indicate that activin A and TNF-alpha exert mutually antagonistic effects on regulating fibroblasts activities, and the balance between their action may determine the process and outcome of fibroblasts-mediated inflammation.
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