Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels

We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographic ancestry and can be used to guide the implementation of PGx clinical decision-support (CDS) tools. We also report that using these panels it is possible to control for the effects of population stratification in association studies in recently admixed populations, as exemplified with a warfarin dosing GWA study in a sample from Brazil.

Automated summary

The study found that the Preemptive PGx and DMET panels performed better in capturing individual admixture proportions in recently mixed populations in the Americas, providing reliable information on biogeographical ancestry and guiding the implementation of individualized genomic clinical decision support tools. Additionally, these panels can help control for population stratification effects in association studies in recently admixed populations, as demonstrated in a warfarin dosing GWA study in a sample from Brazil.