4.7 Article

Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Targeting PI3K in cancer: mechanisms and advances in clinical trials

Jing Yang et al.

MOLECULAR CANCER (2019)

Review Biochemistry & Molecular Biology

Targeted therapeutic options and future perspectives for HER2-positive breast cancer

Jiani Wang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

Article Oncology

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

Pedram Razavi et al.

CANCER CELL (2018)

Review Oncology

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use

George Mihai Nitulescu et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2016)

Review Oncology

The Enigma of Rapamycin Dosage

Suman Mukhopadhyay et al.

MOLECULAR CANCER THERAPEUTICS (2016)

Article Medicine, General & Internal

Pertuzumab, Trastuzumab, and Docetaxel in HER2-Positive Metastatic Breast Cancer

Sandra M. Swain et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Oncology

Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer

Kamal S. Saini et al.

CANCER TREATMENT REVIEWS (2013)

Article Oncology

Somatic Mutation Profiling and Associations With Prognosis and Trastuzumab Benefit in Early Breast Cancer

Sherene Loi et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Article Multidisciplinary Sciences

Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors

Anindita Chakrabarty et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

Kui Lin et al.

SCIENCE SIGNALING (2012)

Review Oncology

The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

Carlos A. Castaneda et al.

CANCER AND METASTASIS REVIEWS (2010)

Article Biochemistry & Molecular Biology

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Morris E. Feldman et al.

PLOS BIOLOGY (2009)

Review Oncology

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

Jeffrey A. Engelman

NATURE REVIEWS CANCER (2009)

Review Medicine, General & Internal

Drug therapy: Trastuzumab - Mechanism of action and use in clinical practice

Clifford A. Hudis

NEW ENGLAND JOURNAL OF MEDICINE (2007)